Plumb’s Veterinary Drug Handbook

Dose --> cats -->5th sentence: "IRIS stage II or greater". Change to "IRIS stage II or III".

Dose-->Cats: For treatment of systemic hypertension (extra-label; reasonable evidence to support): 0.625 – 1.25 mg per cat (¼ - ½ of a 2.5 mg tablet per cat) once daily.

Doses-->Dogs: For acute diarrhea: change 0.25-2 ml/mg to 0.25-2 ml/kg

Doses-->Dogs: For susceptible protozoal infections (anecdotal): Most recommendations for adjunctive treatment for Neospora, Hepatozoon, Babesia, or Toxoplasma infections are 12.5 mg/kg PO twice daily for at least two weeks or longer.

Chemistry --> Change "Ivomec" to "Ivomec Plus®".

Monitoring-->1st bullet: Baseline and ongoing during therapy[ADD":"] CBC (with platelet count).

Doses--> ...PRCA is reported to occur less often [REMOVE: "than"] with darbepoetin…

Doses-->Horses-->"For inducing ovulation within 48 hours in cyclic estrous mares with an ovarian follicle between 30 and 40 mL [change to mm] in diameter..."

Drug Interactions--> second to last bullet titled "DEXAMETHASONE" should say: [BULLET] QUINIDINE

Drug Formulations-->Human-Labeled Products: Diazoxide Oral Suspension: 50 mg[ADD: /mL] with sorbitol in 30 mL calibrated dropper; Proglycem®; (Rx)

Dose--> Cats: 1st paragraph: "...If using the regular tablets, [ADD: "dose"] at 7.5 – 15 mg per cat PO 2-3 times a day; sustained-release product, dose at 30 – 45 mg per cat PO once daily.

Storage/Stability--> Dimenhydrinate products should be stored at room temperature; avoid freezing [REMOVE and] injectable products.

Below phonetic spelling--> Change Dopamine-2 Agonist to Dopamine-2 Antagonist

Dose-->Dogs: For rickettsial diseases such as Rocky Mountain Spotted- Fever (Rickettsia rickettsii); (extra-label): 5 mg/kg PO q12h. (Breitschwerdt 2000) [ADD] Treatment is generally recommended for one week.

Doses-->Dogs-->For adjunctive treatment of proteinuria (extra-label): 3rd sentence-->Most initially will treat at approximately 0.5 mg/kg PO q12h if [REMOVE: cat] [ADD]dog is not azotemic.

Doses--> Birds--> "b) Change 0.01mg.kg to 0.01 mg/kg..."

Doses-->Dogs/Cats-->5th line: Doses used are relative[add "ly"] high 4000 – 6000 Units/kg PO once daily.

1) Compatibility/Compounding Considerations--> 2nd paragraph: If ertapenem is to be given IM, dilute the vial with 3.2 mL of 1% lidocaine HCl injection (without epinephrine). Use within one hour. Do not give [ADD: this concentrated form] IV. 2) Monitoring--> Clinical efficacy. [REMOVE: (WBC, fever, etc.)]

1) Doses--> Dogs: Oral: There is little published supporting any oral esomeprazole dosage in dogs, anecdotally it could be used at similar [REMOVE: "-ly"] dosage rates as oral omeprazole (0.5 – 1.5 mg/kg PO once daily on an empty stomach). 2) Doses-->Cats: As a PPI to reduce gastric acid production (extra- label): Although there is little published supporting any oral esomeprazole dosage in cats, anecdotally it could be used at similar [REMOVE: "-ly"] dosage rates as oral omeprazole (0.5 – 1.5 mg/kg PO once daily on an empty stomach). 3) Doses-->Horses: 1st paragraph--> PO/NG: "... increased gastric pH>5 when measured [REMOVE: "("] 90 minutes-6 hours after a dose."

Doses: Dogs [add "& Cats"]

Doses--> a) [middle of paragraph] ...follow-up CRI doses of 0.05 [ADD 0.5] mL/kg/hour can be continued until clinical signs improve (not to exceed 24 hours).

Contraindications/Precautions/Warnings--> In humans, felbamate should not be used in patients with a history of blood dyscrasias or hepatic dysfunction. [Add] There is a lack of evidence that felbamate causes liver toxicity in dogs. While felbamate should be used with caution in dogs with hepatic impairment, dogs that require it for seizure control are often close to being euthanized and the benefits may outweigh any potential risks. [Remove: Use with caution in dogs with hepatic impairment. Dogs that require felbamate are often close to euthanasia and there is a lack of evidence that felbamate causes liver toxicity in dogs.]

1) Dose-->Cats-->2nd paragraph: "Adult cats (>6 mos. old), and pregnant cats: 100 mg[ADD: "/kg"] PO once. 2) Doses-->Swine: For whipworms in potbellied pigs (extra-label): 9 mg/kg PO for [ADD: 3] days.

1) Contraindications/Precautions/Warnings: Brands are now available that potentially can be cut, but with the availability of 12 m[ADD:c]g patches there is little therapeutic reason to do so. 2) Doses: 1) 12 m[ADD:c]g patches are available for very small cats. (Hansen 2008) 2) Label the site with the size of patch ([ADD: 12, 25, 50, 75, or 100 mcg/hr) and the date and time the patch was placed.

Doses-->Dogs/Cats: Some have suggested dosages as low as 1 microgram/kg [ADD: SC] daily and up to 5 micrograms/kg SC twice daily.

1) Uses/Indications--> Delete last sentence: While oral forms are available, they are not routinely used in veterinary patients.2) Doses-->Dogs/Cats-->Add in new paragraph under ""For adjunctive therapy for acute adrenocortical insufficiency..."" [BOLD] For long term treatment of hypoadrenocorticism (extra-label): In the changeover period as animals recover from an acute crisis, start eating and drinking, and are changed from parenteral to oral medication, traditionally a semi-selective mineralocorticoid (fludrocortisone) and a semi-selective oral glucocorticoid (cortisone acetate, hydrocortisone or prednisolone) are initially used together. Fludrocortisone can be discontinued in a proportion of patients after 1-2 months. When using oral hydrocortisone tablets, most hypoadrenocorticoid dogs are started on an anecdotal dose of 0.4 – 0.8 mg/kg PO q12-24h. Once stable, generally a dose of 0.4 mg/kg PO q12-24h provides adequate additional glucocorticoid supplementation.

Prescriber Highlights: 3rd bullet: Contraindications: [REMOVE: Severe] [CAPITALIZE: H]eart...

1) Doses [bullet]Horse-->1st sentence: "...; most sources indicate that 2.2-4.4 mg/kg given IM once [ADD: is] effective." 2) Doses [bullet]Dogs-->[ADD in BOLD] Warning: Some references recommend using atropine at 0.5 mg/kg SC as a pre-med to mitigate the muscarinic effects of imidocarb in dogs. This is a decimal point error that can lead to tachycardia and other antimuscarinic effects. A more reasonable dose would be 0.05 mg/kg SC. ... Treatment for Babesiosis:

Compatibility/Compounding Considerations--> last paragraph: "and bringing to volume of 200 mL [ADD: with] Ora-Sweet yields a 20 mg/ml..."

1) Drug Interactions-->Cetirizine--> In horses, ivermectin given 12 (but not 1.5) hours prior to cetirizine, increased cetirizine plasma AUC, ... 2) Doses-->Birds-->a) For ascarids...Macaws: 0.2 mg IM[ADD: "."] [DELETE: ; Finches: 0.0.2 mg.] Keep (Stunkard 1984) 3) Dosage Forms/Regulatory Status-->Veterinary Products-->last paragraph--> Ivermectin Medicated feeds: Ivomec(R) Premix for Swine Type A Medicated Article [REMOVE: ")"] 0.6%... 4) Ivermectin/Pyrantel Oral Tablets: 68 mcg/57 mg, 136 mcg/114 mg, 272 mcg/22[REMOVE: 8] [ADD: 7] mg; Heartgard® Plus Chewables, generic; (Rx). FDA-approved for use in dogs.

Prescriber highlights-->1st bullet-->second sentence-->"Still a low- cost/effective treatment for Malassezia dermatitis in dogs[REMOVE: "including aspergillosis, cryptococcal meningitis, blastomycosis, & histoplasmosis"]; also used to reduce dose/costs of cyclosporine therapy..."

Overdosage/Acute Toxicity-->2nd paragraph-->last sentence: "Of the 98 cats, 7 were symptomatic with 29% [REMOVE: hyper] [ADD: hypo]tensive, 29% tachycardic[ADD: ","] and 29% vomiting."

Monitoring-->last sentence: Physical signs associated with hypomagnesemia [ADD:(ie, weakness, muscle fibrillation, ataxia/depression, hyperreflexia, behavior changes, arrhythmias)] and hypermagnesemia [ADD:(ie, hyporeflexia, hypotension, respiratory paralysis, ECG changes, nausea/vomiting). ] [REMOVE: (loss of deep tendon reflexes, hypotension, respiratory paralysis).]

Extra-Label Doses: Oral: The panel of the publication “Best practice for the pharmacological management of hyperthyroid cats with antithyroid drugs” (Daminet et al. 2014) recommends an initial dosage of using 2.5 mg per cat PO twice a day; an initial dose of 5 mg[DELETE:/kg] [ADD: per cat] PO twice a day can be used in cases of extremely elevated total T4 (TT4).

Dosage Formulations-->Veterinary-labeled products--> Methionine Gel: 480 mg/6 gm (6 gm= 5 mL or 1 teaspoon) in 4.25 ounce tubes; Methigel®; (OTC)

Repro safety--> Small amounts of [ADD: the related drug] thiopental have been detected in milk following administration of large doses to humans. -Doses: Dogs: For induction with premedication: 5 mg/kg [ADD: IV]

Contraindications-->last sentence of last paragraph: One reference suggests based upon anecdotal experience, reducing the CRI [ADD: by]25-50% of standard dosage...

Drug class in header: [REMOVE] antiparasitic and [ADD] antiprotozoal

1) Doses-->Swine--> 40 mg [REMOVE: of] PO daily for two days;... 2) Prescriber Highlights-->ADD additional bullet to the bottom that states: Do not crush or allow patients to chew capsules or tablets.

Drug Interactions-->First bullet-->REMOVE and REPLACE with: [BULLET/BOLD] Phosphate Binding Agents[END BOLD] ([ITALIC/NO BOLD: e.g.,] [BEGIN BOLD] oral aluminum and calcium salts, sevelamer, lanthanum carbonate): [END BOLD] May reduce phosphorous levels.

Doses-->Dogs-->Provocative test for narcolepsy/cataplexy-->Subsequent testing can be done at doses of 0.075 mg/kg and [REMOVE: 1][add: 0.1] mg/kg as above.

Storage/Stability-->Commercial products should be stored at 20°-25° C (68°-77°F); excursions permitted to 15°-30°C (59°-86°F). The manufacturer recommends discarding any unused portion from the vial or ampule and does not recommend mixing with any other drug or chemical.

Propranolol --> Doses --> Dogs/Cats --> For susceptible cardiac arrhythmias --> "a maximum of 1 mg/kg" should be changed to "a maximum of 0.1 mg/kg"

OVERDOSAGE/ACUTE TOXICITY: Clinical signs of significant overdose after systemic administration may include arrhythmias (bradycardia, tachycardia, heart block, extrasystoles), hyp[DELETE:er][add:o]kalemia, hypertension, fever, vomiting, …

Reproductive/Nursing Safety--> Change Trazadone to Tramadol

Reproductive/Nursing Safety--> Change Tramadol to Trazodone

Doses--> CATTLE-->For sedation/analgesia:..."When used IV [REMOVE "/"; ADD "or"] IM, analgesia..."

Adverse effects--> ADD "use." after following

1st row of table-->topical-->comments: Doses >1 drop rarely indicated in small animals (maximum tear capacity is 10–20 m[ADD:icro]l[ADD:iters], volume of a drop is 25–50 m[ADD:icro]l[ADD:iters]); allow 5 minutes between drops; instill in order of least viscous to most; instill in order of aqueous prior to oil base.

1) Prescriber Highlights: Given orally in food to stimulate [DELETE:salivation] [ADD: lacrimation] to treat neurogenic keratoconjunctivitis sicca. 2) Uses/Indications: ...pilocarpine was used orally (in food) to induce [DELETE:salivation] [ADD: lacrimation] to treat neurogenic keratoconjunctivitis sicca. 3) Monitoring: Clinical efficacy. Adequate [DELETE:salivation] [ADD: lacrimation] from oral pilocarpine for neurogenic keratoconjunctivitis sicca.

Imidazolines: Change "Domitor" to "Antisedan"