Plumb’s Veterinary Drug Handbook

Ninth Edition Errata

Below is a list of the errors that were found in the first printing of the Plumb’s Veterinary Drug Handbook, Ninth Edition. These errors have already been resolved in the content on the Plumb’s app and website.

View PDF
See eighth edition errata

List of Errata and Corrections

Page numbers are included for desk and pocket editions. Please make note of these changes in your book.

page # desk
page # pocket
change
Systemic Monographs
Alprazolam
38
52

Drug Interactions–>Tricyclic Antidepressants (2nd sentence): However, concurrent use may [REMOVE decrease] [REPLACE with increase] the risk of CNS and/or respiratory depression.

Aspirin
94
131

Dosages–>Cats–>Antithrombotic (5th sentence): A randomized, prospective multicenter study of cats with a prior thromboembolic event found that high-dose aspirin at 81 mg/cat PO every 72 h was inferior…

Bupivacaine HCl
144
199

Dosages–>Dogs–>Local analgesia: b) Using 0.5% bupivacaine solution, 0.5 mg/kg combined with dexmedetomidine 0.1 [REMOVE mg] [REPLACE with µg]/kg.

Buprenorphine HCl
148
205

Pharmacokinetics–>In cats, buprenorphine is rapidly and completely absorbed when given IM [REMOVE: but bioavailability may only be around 50%].

Calcitonin Salmon
167
232

Uses/Indications–>In small animals, calcitonin has been used as adjunctive therapy to control hypercalcemia. It potentially may be of use [REMOVE: as an adjunct to chemotherapy for canine mast cell tumors or] in the adjunctive treatment of pain, particularly when originating from bone.

Cetirizine HCl
234
325

Drug Interactions–>REPLACE entire content in the P-glycoprotein bullet with: P-GLYCOPROTEIN SUBSTRATES (eg, cyclosporine, digoxin, ivermectin, vincristine): Cetirizine was shown to be a p-glycoprotein inhibitor; therefore, avoidance or care should be taken with co-administration of cetirizine with p-glycoprotein substrate drugs.

Chlorpheniramine
248
343

Drugs Interactions–>MAO Inhibitors (including [REMOVE amitriptyline] amitraz, [REMOVE and possibly] selegiline)

Clorazepate Dipotassium
291
402

Drug Interactions–>Tricyclic Antidepressants (2nd sentence): However, concurrent use may [REMOVE decrease] [REPLACE with increase] the risk of CNS and/or respiratory depression.

Cyclosporine
309
428

Dosages–>Dogs–>–>Perianal fistulas (anal furunculosis); (extra-label): …Cyclosporine (alone) 5 – 7.5 mg [ADD: /kg] PO every 24 hours OR 2.5 – 3 mg/kg PO every 24 hours with ketoconazole 2.5 – 5 mg/kg PO every 24 hours.

Darbepoetin Alfa
327
452

Reproductive/Nursing Safety–>2nd paragraph, 1st sentence–>…rabbits demonstrated no overt teratogenicity at daily doses of up to 20 [REMOVE mg][REPLACE with µg]/kg

Dexmedetomidine
351
486

Dosage Forms/Regulatory Status–>VETERINARY-LABELED PRODUCTS: Dexmedetomidine Oromucosal Gel 0.[ADD:0]9 mg/mL (equivalent to 0.1 mg/mL dexmedetomidine HCl) in 3-mL dosing syringes; Sileo® (Rx). FDA-approved for use in dogs (NADA 141-456).

Diazepam
358
496

Drug Interactions–>Tricyclic Antidepressants (2nd sentence): “However, concurrent use may [REMOVE: decrease] [REPLACE: with increase] the risk of CNS and/or respiratory depression.

Enrofloxacin
427
591

Dosages–>Dogs–>Extra-label use of the 2.27% (22.7 mg/mL) injection: 10 – 20 mg/kg every 24 hours IM, SC (must be diluted in saline) or IV depending on the susceptibility and site of the infection. If using IV, the [CHANGE 22.7% to 2.27% (22.7 mg/mL)] injection is first diluted into sterile saline (0.9% sodium chloride) at approximately 10 times the volume of the enrofloxacin.

Epinephrine
431
597

Pharmacology/Actions–> If given at a low dose IV (0.01 mg/kg), it directly stimulates cardiac beta-1 receptors to cause increased heart rate and contractility with resultant increased cardiac output [remove and].

Famotidine
466
646

Dosages–>Dogs–>CHANGE to Dogs & Cats

Gapapentin
530
752

Compatibility/Compounding Considerations–>3rd sentence…retains more than 90% potency for [REMOVE: 56 days stored at both 4°C and 25°C][REPLACE with: 91 days when stored at 4°C (39.2°F) and 56 days when stored at 25°C (77°F).]

Gonadorelin
555
770

Dosages–>Cattle–>Using with cloprostenol sodium to synchronize estrous cycles…Administer 86 micrograms IM (2mL; Fertagyl® or Cystorelin®) or 100 micrograms IM [REMOVE: or IV] (1 mL; GONABreed®)

Heparin Sodium
565
783

Drug Type: Unfractionated Heparin, UHF [CHANGE to UFH]

Levetiracetam
680
943

Pharmacokinetics–>3rd paragraph, [CHANGE 3rd sentence to read: When immediate release and extended release tablets were crushed and administered orally at a dose of 30 mg/kg maximum plasma concentration, terminal half-life, bioavailability, and clearance/bioavailability were 50.72 micrograms/mL and 53.58 micrograms/mL, 6.38 hours and 7.07 hours, 96% and 98%, and 76.8 mL/kg/h and 76.8 mL/kg/h,11 respectively, and time to peak concentration was 0.66 hours and 0.64 hours respectively.]

Levothyroxine
684
948

Dosages–>Cats–>Post antithyroid medication, thryoidectomy, or radioiodine treatment: …0.1 mg [REMOVE /kg][REPLACE with per cat (NOT mg/kg)]

Lorazepam
710
986

Drug Interactions–>Tricyclic Antidepressants (2nd sentence): “However, concurrent use may [REMOVE decrease] [REPLACE with increase] the risk of CNS and/or respiratory depression.

Methimazole
505
1071

Dosages–>Cats–>…an initial dose of 5 mg/[REMOVE kg][REPLACE with cat] PO twice a day.

Pancuronium Bromide
903
1253

Dosages–>Horses–> 0.12 – [ADD: 0.2] mg/kg IV

Pyrantel Pamoate
1014
1405

Drug Interactions–>First paragraph–>The following drug interactions have either been reported or are theoretical in humans or animals receiving [REMOVE propranolol][REPLACE with pyrantel pamoate] and may be of significance in veterinary patients.

Ronidazole
1051
1455

Dosages–>Dogs–> 30 – 50 mg [ADD:/kg] PO twice daily for 7 days.

Sertraline
1064
1478

Drug Interactions–>[ADD–> L-THYROXINE: Sertraline may increase levothyroxine requirements.]

Terbutaline
1120
1555

Overdose/Acute Toxicity–>Clinical signs of significant overdose after systemic administration may include arrhythmias (bradycardia, tachycardia, heart block, extrasystoles), [CHANGE: hyperkalemia to hypokalemia], hypertension, fever, vomiting, mydriasis, and CNS stimulation.

Trilostane
1181
1641

Dosages–>Cats–>Feline Hyperadrenocorticism: …Average dosages were 4.3 mg/kg PO once daily or 3.3 [REMOVE: kg/kg][REPLACE with mg/kg] PO every 12 hours.

Ophthalmic Products
Dexamethasone Ophthalmic
1261
1750

Dosage Forms / Regulatory Status–>Human-Labeled Combination Products–>Neomycin and Polymyxin B Sulfates and Dexamethasone Ophthalmic Suspension (containing neomycin sulfate equivalent to neomycin [CHANGE 2.5 mg to 3.5 mg], polymyxin B sulfate 10,000 units, dexamethasone 0.1%, benzalkonium chloride 0.004%, hypromellose 2910 0.5%, sodium chloride, polysorbate 20, HCl and/or NaOH to adjust pH, purified water): In a 5-mL sterile ophthalmic dropper bottle; Maxitrol®, Dexasporin®; (Rx).

Tafluprost Ophthalmic
1301
1805

Contraindications–> It should not be used in [ADD: pregnant patients or in] the presence of intraocular inflammation (uveitis), as it will worsen this condition.
Client Information: [ADD: This drug has a very high risk for causing miscarriages or birth defects and it should generally not be used in households with pregnant women present.]

Never miss an update

Subscribe to Plumb’s and get instant access to essential updates, including new drugs and updates to existing drugs, written and reviewed by an expert team of veterinarians and veterinary pharmacists.

Explore Plumb’s