Plumb’s Veterinary Drug Handbook

Drug Interactions–>Tricyclic Antidepressants (2nd sentence): However, concurrent use may [REMOVE decrease] [REPLACE with increase] the risk of CNS and/or respiratory depression.

Dosages–>Cats–>Antithrombotic (5th sentence): A randomized, prospective multicenter study of cats with a prior thromboembolic event found that high-dose aspirin at 81 mg/cat PO every 72 h was inferior…

Dosages–>Dogs–>Local analgesia: b) Using 0.5% bupivacaine solution, 0.5 mg/kg combined with dexmedetomidine 0.1 [REMOVE mg] [REPLACE with µg]/kg.

Pharmacokinetics–>In cats, buprenorphine is rapidly and completely absorbed when given IM [REMOVE: but bioavailability may only be around 50%].

Uses/Indications–>In small animals, calcitonin has been used as adjunctive therapy to control hypercalcemia. It potentially may be of use [REMOVE: as an adjunct to chemotherapy for canine mast cell tumors or] in the adjunctive treatment of pain, particularly when originating from bone.

Drug Interactions–>REPLACE entire content in the P-glycoprotein bullet with: P-GLYCOPROTEIN SUBSTRATES (eg, cyclosporine, digoxin, ivermectin, vincristine): Cetirizine was shown to be a p-glycoprotein inhibitor; therefore, avoidance or care should be taken with co-administration of cetirizine with p-glycoprotein substrate drugs.

Drugs Interactions–>MAO Inhibitors (including [REMOVE amitriptyline] amitraz, [REMOVE and possibly] selegiline)

Drug Interactions–>Tricyclic Antidepressants (2nd sentence): However, concurrent use may [REMOVE decrease] [REPLACE with increase] the risk of CNS and/or respiratory depression.

Dosages–>Dogs–>–>Perianal fistulas (anal furunculosis); (extra-label): …Cyclosporine (alone) 5 – 7.5 mg [ADD: /kg] PO every 24 hours OR 2.5 – 3 mg/kg PO every 24 hours with ketoconazole 2.5 – 5 mg/kg PO every 24 hours.

Reproductive/Nursing Safety–>2nd paragraph, 1st sentence–>…rabbits demonstrated no overt teratogenicity at daily doses of up to 20 [REMOVE mg][REPLACE with µg]/kg

Dosage Forms/Regulatory Status–>VETERINARY-LABELED PRODUCTS: Dexmedetomidine Oromucosal Gel 0.[ADD:0]9 mg/mL (equivalent to 0.1 mg/mL dexmedetomidine HCl) in 3-mL dosing syringes; Sileo® (Rx). FDA-approved for use in dogs (NADA 141-456).

Drug Interactions–>Tricyclic Antidepressants (2nd sentence): “However, concurrent use may [REMOVE: decrease] [REPLACE: with increase] the risk of CNS and/or respiratory depression.

Dosages–>Dogs–>Extra-label use of the 2.27% (22.7 mg/mL) injection: 10 – 20 mg/kg every 24 hours IM, SC (must be diluted in saline) or IV depending on the susceptibility and site of the infection. If using IV, the [CHANGE 22.7% to 2.27% (22.7 mg/mL)] injection is first diluted into sterile saline (0.9% sodium chloride) at approximately 10 times the volume of the enrofloxacin.

Pharmacology/Actions–> If given at a low dose IV (0.01 mg/kg), it directly stimulates cardiac beta-1 receptors to cause increased heart rate and contractility with resultant increased cardiac output [remove and].

Dosages–>Dogs–>CHANGE to Dogs & Cats

Compatibility/Compounding Considerations–>3rd sentence…retains more than 90% potency for [REMOVE: 56 days stored at both 4°C and 25°C][REPLACE with: 91 days when stored at 4°C (39.2°F) and 56 days when stored at 25°C (77°F).]

Dosages–>Cattle–>Using with cloprostenol sodium to synchronize estrous cycles…Administer 86 micrograms IM (2mL; Fertagyl® or Cystorelin®) or 100 micrograms IM [REMOVE: or IV] (1 mL; GONABreed®)

Drug Type: Unfractionated Heparin, UHF [CHANGE to UFH]

Pharmacokinetics–>3rd paragraph, [CHANGE 3rd sentence to read: When immediate release and extended release tablets were crushed and administered orally at a dose of 30 mg/kg maximum plasma concentration, terminal half-life, bioavailability, and clearance/bioavailability were 50.72 micrograms/mL and 53.58 micrograms/mL, 6.38 hours and 7.07 hours, 96% and 98%, and 76.8 mL/kg/h and 76.8 mL/kg/h,¹¹ respectively, and time to peak concentration was 0.66 hours and 0.64 hours respectively.]

Dosages–>Cats–>Post antithyroid medication, thryoidectomy, or radioiodine treatment: …0.1 mg [REMOVE /kg][REPLACE with per cat (NOT mg/kg)]

Drug Interactions–>Tricyclic Antidepressants (2nd sentence): “However, concurrent use may [REMOVE decrease] [REPLACE with increase] the risk of CNS and/or respiratory depression.

Dosages–>Cats–>…an initial dose of 5 mg/[REMOVE kg][REPLACE with cat] PO twice a day.

Dosages–>Horses–> 0.12 – [ADD: 0.2] mg/kg IV

Drug Interactions–>First paragraph–>The following drug interactions have either been reported or are theoretical in humans or animals receiving [REMOVE propranolol][REPLACE with pyrantel pamoate] and may be of significance in veterinary patients.

Dosages–>Dogs–> 30 – 50 mg [ADD:/kg] PO twice daily for 7 days.

Drug Interactions–>[ADD–> L-THYROXINE: Sertraline may increase levothyroxine requirements.]

Dosages–>Rabbits–>Anesthesia (extra-label): Following a medetomidine and carprofen premedication, sufentanil 0.5 micrograms/kg with midazolam 0.1 mg/kg combined in one syringe and given IV for induction achieved smooth anesthesia within 5 minutes which was maintained during surgery with sufentanil [REMOVE 3.9][REPLACE with 0.72] micrograms/kg per hr and midazolam 0.8 mg/kg/hr IV CRI.

Overdose/Acute Toxicity–>Clinical signs of significant overdose after systemic administration may include arrhythmias (bradycardia, tachycardia, heart block, extrasystoles), [CHANGE: hyperkalemia to hypokalemia], hypertension, fever, vomiting, mydriasis, and CNS stimulation.

Dosages–>Small Mammals–>Analgesic–>Sugar gliders: 2 – 6 [REMOVE mg/mg][REPLACE with: mg/kg] PO every 12 hours

Dosages–>Cats–>Feline Hyperadrenocorticism: …Average dosages were 4.3 mg/kg PO once daily or 3.3 [REMOVE: kg/kg][REPLACE with mg/kg] PO every 12 hours.

Dosages–>DOGS/CATS–>Adjunctive treatment of hypotension, shock (extra-label):
a) Adjunctive post-CPCR treatment: From the RECOVER guidelines: Vasopressin 0.5 – 5 milliUnits/kg/minute ([REMOVE: 0.003 – 0.03][REPLACE with 0.03 – 0.3] Units/kg/hour) IV CRI.
d) Hypotension that persists in dogs despite volume resuscitation (found in septic shock); may be an indication for vasopressin (extra-label): 0.5 – 5 milliUnits/kg/minute ([REMOVE: 0.003 – 0.03][REPLACE with 0.03 – 0.3] Units/kg/hour) IV CRI

Dosage Forms / Regulatory Status–>Human-Labeled Combination Products–>Neomycin and Polymyxin B Sulfates and Dexamethasone Ophthalmic Suspension (containing neomycin sulfate equivalent to neomycin [CHANGE 2.5 mg to 3.5 mg], polymyxin B sulfate 10,000 units, dexamethasone 0.1%, benzalkonium chloride 0.004%, hypromellose 2910 0.5%, sodium chloride, polysorbate 20, HCl and/or NaOH to adjust pH, purified water): In a 5-mL sterile ophthalmic dropper bottle; Maxitrol®, Dexasporin®; (Rx).

Contraindications–> It should not be used in [ADD: pregnant patients or in] the presence of intraocular inflammation (uveitis), as it will worsen this condition.
Client Information: [ADD: This drug has a very high risk for causing miscarriages or birth defects and it should generally not be used in households with pregnant women present.]